Sermorelin typical research dosing
Across the available literature, Sermorelin is most commonly administered at 100–500 mcg per dose, 1 time(s) per day, via subcutaneous injection. Research protocols typically administer 100–500 mcg subcutaneously once daily at bedtime to align with the natural nocturnal GH surge. Fasting prior to injection is recommended in most protocols to avoid blunting of the GH pulse.
Sermorelin unit-conversion table
The number of insulin-syringe units you draw depends on how much bacteriostatic water you used to reconstitute the vial. The table below shows units to draw on a U-100 syringe for a 2 mg Sermorelin vial at common reconstitution volumes.
| Diluent (mL) | Concentration | 100 mcg | 300 mcg | 500 mcg |
|---|---|---|---|---|
| 1 mL | 2000 mcg/mL | 5.0 units | 15.0 units | 25.0 units |
| 2 mL | 1000 mcg/mL | 10.0 units | 30.0 units | 50.0 units |
| 3 mL | 667 mcg/mL | 15.0 units | 45.0 units | 75.0 units |
| 5 mL | 400 mcg/mL | 25.0 units | 75.0 units | 125.0 units |
Sermorelin cycle length
Most reported Sermorelin protocols run 12 weeks on, then 4 weeks off. Cycles are used in research to study washout, receptor sensitivity, and to re-baseline endogenous signaling before re-introducing the compound.
Sermorelin half-life and timing
Sermorelin has a half-life of approximately 0.25 hours. This influences dose frequency: shorter half-lives often require multiple doses per day to maintain steady-state levels, while longer half-lives can be dosed less frequently.