Lyophilized
Also known as: freeze-dried
Lyophilized refers to the freeze-dried powder form of a peptide. Removing water prevents degradation and allows the peptide to remain stable for 12–24 months without refrigeration.
Overview
Lyophilization is a preservation process that removes water from a frozen solution under vacuum, converting ice directly to vapor without passing through a liquid phase (sublimation). The resulting powder retains the chemical structure of the original peptide in a highly stable state. Most research peptides are shipped and sold in this lyophilized form because it dramatically extends shelf life and reduces cold-chain requirements. Before use, the powder must be reconstituted with a suitable sterile diluent — typically bacteriostatic water — to create an injectable solution. Proper reconstitution technique (slow injection of diluent along the vial wall, gentle swirling rather than shaking) helps preserve peptide integrity.
Related Terms
Frequently asked questions
Does lyophilized peptide need to be refrigerated?+
Lyophilized peptide is stable at room temperature away from light and moisture, but refrigeration or freezing is recommended for storage beyond a few months to maximize shelf life.
How long does a lyophilized peptide last?+
Typically 12–24 months when stored in a cool, dark, dry place. Once reconstituted into solution, shelf life drops to approximately 28–30 days when refrigerated with bacteriostatic water.
Can I freeze lyophilized peptide to extend shelf life further?+
Yes. Storing lyophilized vials at -20°C can extend stability well beyond 24 months. Just ensure the vial is sealed and dry before freezing.